Sequencing drug response with HapMap
نویسندگان
چکیده
منابع مشابه
Sequencing complex diseases With HapMap.
Determining the patterns of DNA sequence variation in the human genome is a useful first step toward identifying the genetic basis of a common disease. A haplotype map (HapMap), aimed at describing these variation patterns across the entire genome, has been recently developed by the International HapMap Consortium. In this article, we present a novel statistical model for directly characterizin...
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Two years ago, when biologists declared victory in sequencing the human genome, the announcement seemed all the more believable because the president of the United States himself was there to share the glory. Two years later, cancer has still not been cured, the major genetic causes of diabetes have not been uncovered, and truth be told, the human genome has still not really been fully sequence...
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With the availability of the HapMap--a resource which describes common patterns of linkage disequilibrium (LD) in four different human population samples, we now have a powerful tool to help dissect the role of genetic variation in the biology of the genome. HapMap is entirely complimentary to the human genome map and so it is particularly fitting that it should be viewed in a full genomic cont...
متن کاملThe International HapMap Project
The goal of the International HapMap Project is to determine the common patterns of DNA sequence variation in the human genome and to make this information freely available in the public domain. An international consortium is developing a map of these patterns across the genome by determining the genotypes of one million or more sequence variants, their frequencies and the degree of association...
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ژورنال
عنوان ژورنال: The Pharmacogenomics Journal
سال: 2005
ISSN: 1470-269X,1473-1150
DOI: 10.1038/sj.tpj.6500302